Todd Phillips' 'Joker' won the Golden Lion award at the Venice Film Festival.
Joker, starring Joaquin Phoenix, had received an eight-minute standing ovation at its premiere in the Italian city on Saturday.
"I want to thank Warner Bros and DC for stepping out of their comfort zone and taking such a bold swing on me and this movie," director Todd Phillips said in his acceptance speech.
"There is no movie without Joaquin Phoenix ... Joaquin is the fiercest and bravest and most open-minded lion that I know."
The movie follows superhero Batman's nemesis' transformation from vulnerable loner to confident villain.
Meanwhile, Roman Polanski's military drama An Officer and a Spy took the Silver Lion Grand Jury Prize.
Italian actor Luca Marinelli won best actor for Martin Eden, while France's Ariane Ascaride won best actress for Gloria Mundi.
Best director went to Sweden's Roy Andersson About Endlessness, while Italian director Franco Maresca won the Special Jury Prize for satirical documentary Mafia Is No Longer What It Used to Be.
Best screenplay went to Chinese filmmaker Yonfan for the animation No. 7 Cherry Lane.
Bulgaria won the Eurovision Song Contest for the first time on Saturday in a final overshadowed by five countries' boycott over Gaza, claiming a dramatic victory despite another big public vote for Israel that again secured it second place.
The Eurovision Song Contest's final takes place in Vienna on Saturday, stung by five nations' boycott over Israel taking part, although protests in the city were muted.
Sheikha Latifa bint Mohammed bin Rashid Al Maktoum, Chairperson of Dubai Culture and Arts Authority, has announced the launch of Museum of Digital Art (MODA).
US screen legend John Travolta, star of hits such as 'Pulp Fiction' and 'Grease', was surprised on Friday with an honorary Palme d'Or prize at the Cannes Film Festival, before the premiere of his directorial debut 'Propeller One-Way Night Coach'.