Several metro stations in Brussels were closed on Wednesday after a shooting at the central Clemenceau station, the Belgian prosecutor's office said.
No injuries were reported, it said.
The suspects fled into the metro tunnels afterwards, a source close to the investigation said, adding that police were looking for two suspects.
Sources close to the investigation told local media the incident may have been drug-related.
Images on VRT's website showed two people walking into the station and opening fire. The images could not immediately be verified by Reuters.

US House blocks bid to impeach Defence Secretary Hegseth
Former Pakistan PM Imran Khan back in jail after medical treatment, sources say
Over 100 Indonesian lawmakers sign petition for vice president's impeachment
9 seriously injured in South Korea bus crash involving 32 vehicles
