England boss Thomas Tuchel will have no choice but to ring the changes ahead of Tuesday's friendly with Japan at Wembley Stadium after eight players left the camp on Saturday with a variety of health issues and injury concerns.
Having drawn 1-1 with Uruguay in a friendly on Friday, the FA announced the departures on Saturday after several players picked up knocks and injuries, causing changes to the 35-man squad selected by Tuchel for the current international break.
Goalkeeper Aaron Ramsdale, Fikayo Tomori, and Dominic Calvert-Lewin are among the departures, with defender John Stones returning to Manchester City after picking up an injury before Friday's game, while Adam Wharton (Crystal Palace) and Noni Madueke (Arsenal) were both injured in the friendly.
Madueke's Arsenal teammates Declan Rice and Bukayo Saka have also returned to the North London club.
FIFA has expanded the squad size at the World Cup in the US, Mexico, and Canada this year to 26 players. England take on Croatia, Ghana and Panama in Group L, kicking off against the Croatians in Arlington, Texas, on June 17.
Abhishek Sharma's 19-ball fifty went in vain as world champions India were surprisingly beaten by Ireland for the first time in international cricket, slumping to a 34-run defeat in the first Twenty20 in Belfast on Friday.
England roared back into contention on the second day of the third and deciding test against New Zealand with Ben Duckett's rapid century helping his side to 223-2 after three wickets for returning captain Ben Stokes helped to dismiss the visitors for 438 at a sizzling Trent Bridge.
American great Serena Williams will face Australian 20-year-old Maya Joint in the first round of her eagerly awaited return to Wimbledon, a potentially tricky tie for the seven-time champion playing at the tournament for the first time since 2022.
Australia booked their spot in the knockout rounds of the World Cup on Thursday after a cagey draw against Paraguay, who are set to qualify as a third-placed finisher, while Turkey beat USA 3-2, scoring the winner with virtually the last kick of the match.
The Netherlands scored two goals in the first seven minutes of the first half en route to a 3-1 victory over Tunisia on Thursday night in Kansas City in Group F, while Japan and Sweden drew 1-1 in Texas.