Jason Roy and captain Joe Root both smashed centuries as the tourists easily reached their target of 361 with eight balls to spare in Barbados.
It was their highest ever run-chase in the format.
Chris Gayle's innings of 139 off 129 balls went in vain as the Windies' poor form in ODI cricket continued.
The second encounter of the five-match series will be played on Friday.
Alcaraz reaches first Paris Masters final, will face Shelton
World number three Carlos Alcaraz edged past Casper Ruud 6-4 6-4 on Saturday to reach his first Paris Masters final, where he will face Ben Shelton, who shook off a slow start to beat local favourite Luca Van Assche 5-7 6-3 6-4.
New Zealand maintain unbeaten record against Scotland with big win
New Zealand kept up their unbeaten record against Scotland, blowing away their hosts in the second half as they won 43-21 in imperious style in their Nations Championship at Murrayfield on Saturday.
Formula One extends Sao Paulo contract to 2035
Formula One will continue to race at Sao Paulo's Interlagos circuit until 2035 after announcing a five-year contract extension on Saturday.
South Africa thump Italy to stay perfect in Nations Championship
South Africa strolled past an injury-hit Italy with a 66-7 win in Saturday's Nations Championship meeting in Turin.
Okafor secures Leeds win at home to Tottenham after red-card controversy
Noah Okafor scored 97 seconds after coming off the bench to give Leeds United a 1-0 win over Tottenham Hotspur in the Premier League on Saturday but the visitors were aggrieved that their hosts had not been reduced to 10 men at Elland Road.
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Giada De Laurentiis Talks 'DWTS', Holiday Cooking Tips & More!
The Saturday Brunch Episode 18: Halloween, Country Music & Shades of Pink
Thursday 29 Nov - Weekend vibes are here EARLY!!
