England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.

Police detain organiser of Messi visit after Indian fans rip up seats
Patel dominates as Mumbai take Game 1 of United Series
UAE though to Arab Cup semi-finals after beating Algeria on penalties
Dubai Basketball claim thrilling win over Bayern Munich in EuroLeague
Salah in Liverpool squad for Brighton match
