According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Sabalenka withdraws from Stuttgart Open due to injury
Aryna Sabalenka has pulled out of this month's Stuttgart Open due to an injury she sustained following her Miami Open triumph in March, the world number one said on Thursday.
Atletico beat 10-man Barca as PSG defeat Liverpool
Atletico Madrid took a firm grip on their Champions League quarter-final as goals from Julian Alvarez and Alexander Sorloth earned a 2-0 first-leg victory over 10-man Barcelona at the Camp Nou.
UAE Team Emirates-XRG claim second place on stage 3 of Itzulia Basque Country
Igor Arrieta has ridden to second place on stage 3 for UAE Team Emirates-XRG during a thrilling finale at Itzulia Basque Country,
Home hero Vacherot thrilled to beat Musetti in Monte Carlo
Monaco's Valentin Vacherot could barely have scripted his second career win over a top-five player better after he defeated world number five Lorenzo Musetti 7-6(6) 7-5 in front of a joyous home crowd at the Monte-Carlo Masters on Wednesday.
Gujarat survive IPL final-over chaos as Miller's gamble backfires
Gujarat Titans survived a ferocious late assault from David Miller to clinch a nerve-shredding one-run win over Delhi Capitals in an Indian Premier League (IPL) thriller on Wednesday.
10:00pm - Midnight
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