According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Alcaraz reaches first Paris Masters final, will face Shelton
World number three Carlos Alcaraz edged past Casper Ruud 6-4 6-4 on Saturday to reach his first Paris Masters final, where he will face Ben Shelton, who shook off a slow start to beat local favourite Luca Van Assche 5-7 6-3 6-4.
New Zealand maintain unbeaten record against Scotland with big win
New Zealand kept up their unbeaten record against Scotland, blowing away their hosts in the second half as they won 43-21 in imperious style in their Nations Championship at Murrayfield on Saturday.
Formula One extends Sao Paulo contract to 2035
Formula One will continue to race at Sao Paulo's Interlagos circuit until 2035 after announcing a five-year contract extension on Saturday.
South Africa thump Italy to stay perfect in Nations Championship
South Africa strolled past an injury-hit Italy with a 66-7 win in Saturday's Nations Championship meeting in Turin.
Okafor secures Leeds win at home to Tottenham after red-card controversy
Noah Okafor scored 97 seconds after coming off the bench to give Leeds United a 1-0 win over Tottenham Hotspur in the Premier League on Saturday but the visitors were aggrieved that their hosts had not been reduced to 10 men at Elland Road.
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Giada De Laurentiis Talks 'DWTS', Holiday Cooking Tips & More!
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