Portugal will fill a slot left vacant by Vietnam and be the third race of the Formula One season on May 2, the sport confirmed on Friday.
The race will again be held at the Algarve circuit near Portimao that made its debut last October on a calendar reduced to 17 races as a result of cancellations due to the COVID-19 pandemic.
That was the first Portuguese Grand Prix in 25 years.
Formula One is planning a record 23 races this year, with the season starting on March 28 in Bahrain.
"We want to thank the promoter and the Portuguese Government for their hard work and dedication in getting us to this point," said Formula One chief executive Stefano Domenicali in a statement.
"We are confident and excited about our 2021 season, having shown last year that we could deliver 17 races safely and bring our millions of fans thrilling racing at a difficult time.
"We hope to welcome fans to Portimao again this season in a safe way and are working with the promoter on the details of that plan."
American great Serena Williams will face Australian 20-year-old Maya Joint in the first round of her eagerly awaited return to Wimbledon, a potentially tricky tie for the seven-time champion playing at the tournament for the first time since 2022.
Australia booked their spot in the knockout rounds of the World Cup on Thursday after a cagey draw against Paraguay, who are set to qualify as a third-placed finisher, while Turkey beat USA 3-2, scoring the winner with virtually the last kick of the match.
The Netherlands scored two goals in the first seven minutes of the first half en route to a 3-1 victory over Tunisia on Thursday night in Kansas City in Group F, while Japan and Sweden drew 1-1 in Texas.
Ecuador coach Sebastian Beccacece said all Ecuadoreans have a lot to celebrate on Thursday after the country's biggest World Cup result ever, coming from behind to beat Germany 2-1 and advance to the knockout stage.
New Zealand took control of the third Test at Trent Bridge with Tom Latham and Devon Conway setting a record partnership for the Kiwis against England on Thursday.