Rafael Nadal showed no signs of a recent knee injury as he eased into the third round of the Monte Carlo Masters with a 6-1, 6-1 win against Roberto Bautista Agut.
The Spaniard next plays Grigor Dimitrov, who beat Germany’s Jan-Lennard Struff 7-6, 6-4.
Elsewhere, fifth-seed Kei Nishikori suffered a 7-5, 6-4 defeat to Frenchman Pierre-Hugues Herbert, while Italy's Fabio Fognini advanced to the next round when France's Gilles Simon withdrew with a back injury.
No. 16 David Goffin of Belgium was the only other seeded player to fall, losing 6-3, 6-4 to Dusan Lajovic of Serbia.
Alexander Zverev, Dominic Thiem, Stefanos Tsitsipas and Daniil Medvedev are some of the other players who’ve advanced to the next round.
Manchester City have halved Arsenal's lead at the top of the Premier League to three points with a 3-0 win overvisitors Fulham, while Aston Villa stayed in the frame with a late 1-0 victory at home to Brighton & Hove Albion on Wednesday.
Sherfane Rutherford struck an unbeaten half-century and Gudakesh Motie produced a brilliant display of spin bowling as West Indies thumped England by 30 runs in a Twenty20 World Cup Group C encounter on Wednesday.
Australia launched their Twenty20 World Cup campaign with a commanding 67-run victory over Ireland in Colombo on Wednesday, powered by four-wicket hauls from Nathan Ellis and Adam Zampa.
Tottenham Hotspur have sacked manager Thomas Frank after eight months in charge, the Premier League club said on Wednesday, after a woeful run of results left the north London club hovering five points above the relegation zone.