World number one Aryna Sabalenka's quest for her first Wimbledon title will begin against Canadian qualifier Carson Branstine while second seed Coco Gauff's opener will be versus Ukraine's Dayana Yastremska.
Friday's draw also pitched defending champion Barbora Krejcikova, the 17th seed, against Alexandra Eala of the Philippines.
Third seed Jessica Pegula's first-round opponent is Italian qualifier Elisabetta Cocciaretto, while fourth seed Jasmine Paolini, runner-up last year, faces Anastasija Sevastova of Latvia.
Belarusian Sabalenka could meet Paolini in the semi-finals while Gauff is in line for a clash with fellow American Pegula.
British number one Emma Raducanu faces an intriguing opening round match against compatriot Mingge Xu, one of three British teenaged wildcards in the draw.
Alcaraz reaches first Paris Masters final, will face Shelton
New Zealand maintain unbeaten record against Scotland with big win
Formula One extends Sao Paulo contract to 2035
South Africa thump Italy to stay perfect in Nations Championship
Okafor secures Leeds win at home to Tottenham after red-card controversy
